某病人单次静脉注射某药物10mg．半小时血药浓度是多少(已知t1/2=4h，V=60L)
0.153μg/mL
0.225μg/mL
0.301μg/mL
0.458μg/mL
0.610μg/mL
本题考查单室模型静脉注射给药的计算公式。半衰期t1/2=0.693/k；单室模型静脉注射给药血药浓度lgC=(-kt/2.303)+lgC0；
k=0.693/t1/2=0.693/4=0.173
lgC=lgC0-kt/2.303=lg10/60-0.173×0.5/2.303=-0.815
故C=0.153μg/mL