When implementing the project, we（ ）a lot of unexpected opposition from our colleagues.
run for
make against
run up against
make away with
考查动词短语辨析。run for“竞选”，make against“不利于”，run up against“遇到，遭遇”，make away with“携……而逃，除去，杀死”。句意为“当实施计划时，我们遭到同事们意料不到的反对”。故选C。